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How does Nucala work

This page is specifically for patients who have been prescribed Nucala. If you are not a patient who has already been prescribed Nucala, please return to the public website.

What does Nucala do?

  • When eosinophils (white blood cells) move from your blood into your lungs, they can cause your airways to become inflamed, increasing the risk of a severe asthma attack
  • Interleukin-5 (IL-5) contributes to the development and survival of eosinophils.
  • Nucala blocks IL-5 binding to eosinophils and reduces the number of eosinophils in your blood, leading to less inflammation in your lungs
Pathway 2

Should I continue my existing medication

  • Yes. Nucala is an add-on treatment, which means you should continue to take your other medications as prescribed by your doctor. 
  • It is recommended that all patients with asthma have an asthma action plan. 
  • If you have any questions, please ask your doctor or nurse at your next appointment.

Nucala is a registered trademark of the GlaxoSmithKline group of companies

Adverse events should be reported. Reporting forms and information can be found at or search for MHRA Yellowcard in the Google Play or Apple App store. Adverse events should also be reported to GlaxoSmithKline on 0800 221 441.